伴随着现代医学海量数据的积累及国家对精准医学研究的高度重视和支持，我国生物统计学科正在快速发展。如何利用现代生物统计学和生物信息学理论工具驱动和深化对转化和临床医学研究中的各类数据的分析理解将积极影响国家 “ 十三五 ” 规划中生物医学支柱产业的发展。尤其是包括基因测序和电子医疗病历大数据的迅速累积为现代生物统计学的发展带来了巨大的机遇和积极的挑战。同时生物统计学科的发展对推动从 “ 一体适用 ” 的传统医学研发观念迈向 “ 量身定制 ” 的精准医学思想和实践将发挥关键作用。 “交大-耶鲁生物统计联合中心”结合国内外一流的生物统计研究团队，面向精准医学及医疗大数据研究前沿，努力引领和推动国内外医学数据科学研究。为此，数据驱动健康医学研讨会隆重邀请国际顶级生物统计学专家，精准医学专家，科研机构与您分享讨论国际医疗大数据和精准医学最新前沿。近距离和包括Wing Hung Wong(美国科学院院士，美国医学院院士，斯坦福大学)，Paul D.Cleary （美国医学科学院院士，耶鲁大学）， Xihong Lin（哈佛大学），赵国屏（中科院院士），Hongyu Zhao（耶鲁大学）等国际顶级医学和生物统计学大师对话将为您的医学研究开启新的视野。
本次研讨会主题为精准医疗与大数据。包括如下议题：1. 精准治疗；2. 统计基因组学；3. 精准临床试验设计；4. 电子医疗病历研究及应用；5.大队列分析；6.健康大数据
Conference Program
2016/6/30 (Thursday)
8:00 – 8:30 Registration
8:30 – 9:00 Opening Ceremony(Chair: Hui Lu)
Opening remarks from the leaders
Center Progress Report by
Hongyu Zhao, Director of the SJTU-Yale Joint Center for Biostatistics, Professor, Yale University
9:00 – 10:00 Plenary Lecture 1: Dissecting the regulatory elements of the genome
Plenary Speaker: Wing Wong, Professor, Stanford University
Chair:Hongyu Zhao
10:00 – 10:25 Tea Break (Photo)
10:25 – 11:45 Invited Session 1: Computational Biology
Chair:Hui Lu
10:25 – 10:45 Invited Speaker: X. Shirley Liu, Professor, Harvard University
Title: CRISPR screens for precision cancer medicine
10:45 – 11:05 Invited Speaker:李程，教授，北京大学
Title: Co-expression and network motif models of cancer expression profiles
11:05 – 11:25 Invited Speaker:陈洛南，研究员，中国科学院
Title: Detecting early-warning signals for complex diseases by dynamical network biomarkers
11:25 – 11:45 Invited Speaker: 韦朝春，教授，上海交通大学
Title: How many protein isoforms are encoded in the human genome?
11:45 – 13:30 Lunch
13:30 – 14:15 Plenary Lecture 2: Statistical Analysis of Whole Genome Array and Sequencing Association Studies
Plenary Speaker: Xihong Lin, Professor, Harvard University
Chair:Zhangsheng Yu
14:15 – 15:15 Invited Session 2: Health Informatics
Chair:Daru Lu
14:15 – 14:35 Invited Speaker: Hua Xu, Professor, University of Texas Health Science Center
Title: Healthcare Analytics using EHR–Technologies and Applications
14:35 – 14:55 Invited Speaker: Rui Xiao, Associate Professor, University of Pennsylvania
Title: Using Electronic Health Record (EHR) Data to Promote Clinical Research in Pediatric Practices
14:55 – 15:15 Invited Speaker:黄伟，副教授，东北师范大学
Title: An Empirical Bayesian Model for Health-Care Data analysis
15:15 – 15:40 Tea Break
15:40 – 17:20 Invited Session 3: Clinical Trials
Chair:Tao Wang
15:40 – 16:00 Invited Speaker: Ying Yuan, Professor, MD Anderson Cancer Center
Title: Optimal Marker-Adaptive Designs for Targeted Therapy Based on Imperfectly Measured Biomarkers
16:00 – 16:20 Invited Speaker: Ying Zhang, Professor, Indiana University
Title: Nonparametric Inference with Misclassified Competing Risks Data
16:20 – 16:40 Invited Speaker: Naitee Ting, Senior Principal Statistician, Boehringer Ingelheim Pharmaceuticals
Title: A Simple and Efficient Statistical Approach for Designing an Early Phase II Clinical Trial
16:40 – 17:00 Invited Speaker: Ming Yuan, Professor, University of Wisconsin-Madison
Title: Optimal Correlation Detection with Application to Colocalization Analysis in Dual-Channel Florescence Microscopic Imaging
17:00 – 17:20 Invited Speaker:王炳顺，副教授，上海交通大学医学院
Title:Clinical Research Based on Big Health Care Data
2016/7/1 (Friday)
8:30 – 9:15 Plenary Lecture 3: Statistical strategies in health service research
Plenary Speaker: Paul D. Cleary, Professor, Yale University
Chair: Hui Lu
9:15 – 10:15 Invited Session 4: Big Data in Health
Chair: Bingshun Wang
9:15 – 9:35 Invited Speaker: Ying Lu, Professor, Stanford University
Title: Cross-sectional design with a short-term follow-up for prognostic imaging biomarkers
9:35 – 9:55 Invited Speaker: Hongye Sun, VP of Operation Technology Platform, WuXi Apptec Inc
Title: TBD
9:55 – 10:15 Invited Speaker: Herbert Pang, Associate Professor, University of Hong Kong
Title: Integrative Pathway Analysis Using Graph-Based Learning
10:15 – 10:40 Tea Break
10:40 – 12:00 Invited Session 5: Statistical Methods
Chair: Hua Zhong
10:40 – 11:00 Invited Speaker: Peter X.K. Song, Professor, University of Michigan
Title: Study Design in High-Dimensional Classification Analysis
11:00 – 11:20 Invited Speaker:俞章盛，教授，上海交通大学
Title: Structure Discovery for Joint Models through Variable Selection Approaches
11:20 – 11:40 Invited Speaker: Tiejun Tong, Associate Professor, Hong Kong Baptist University
Title: Regularized t distribution and its applications
11:40 – 12:00 Invited Speaker: Can Yang, Assistant Professor, Hong Kong Baptist University
Title: A Summary-Statistics-based approach to Estimating heritability, co-heritability and effect sizes in GWAS data analysis
12:00 – 13:30 Lunch
13:30 – 14:50Invited Session 6: Big Data in Medicine
Chair: Can Yang
13:30 – 13:50Invited Speaker: Hongyu Zhao, Director, SJTU-Yale Joint Center for Biostatistics, Professor, Yale University
Title: Integrated Analysis of Genome Wide Association Signals and Genomic Annotations
13:50 – 14:10 Invited Speaker:韩宝惠，教授，上海市胸科医院
Title: Precision medicine for lung cancer
14:10 – 14:30Invited Speaker: Yi Li, Professor, University of Michigan
Title: Generalized Linear Mixed Models with Gaussian Mixture Random Effects
14:30 – 14:50 Invited Speaker:赵东升，研究员，军事医学科学院
Title: Construction of China Stoke Data Center and Its Application
14:50 – 15:15 Tea Break
15:15 – 16:55Invited Session 7: Statistical Genetics and Genomics
Chair: Minghua Deng
15:15 – 15:35 Invited Speaker:Mingyao Li, Associate Professor, University of Pennsylvania
Title: Accounting for technical batch effects in single-cell RNA sequencing analysis
15:35 – 15:55 Invited Speaker: Qi Long, Associate Professor, Emory University
Title: Scalable Bayesian Variable Selection for Structured High-dimensional Data
15:55 – 16:15 Invited Speaker: 胡跃清，教授，复旦大学
Title: Detecting Multiple Variants Associated with Disease Based on Sequencing Data of Case-Parent Trios
16:15 – 16:35 Invited Speaker: Dajiang Liu, Assistant Professor, Pennsylvania State University
Title: Meta-analysis of Gene-level Association Tests Offers Biological and Clinical Insights for Lipids Levels
16:35 – 16:55 Invited Speaker:张淑芹，副教授，复旦大学
Title: Functional Module Analysis in Multiplex Biological Networks
2016/7/2 (Saturday)
8:30 – 9:15 Plenary Lecture 5:Hyperlipidemia-associated variations and expression patterns revealed by whole-genome and transcriptome sequencing of rabbit models
Plenary Speaker: 李亦学，研究员，中国科学院
Chair: 田卫东
9:15 – 10:15 Invited Session 8: Bio-IT in Translational Medicine
Chair: 马炯
9:15 – 9:35 Invited Speaker: 吕晖，教授，上海交通大学
Title: 数据驱动的基因型与表型整合分析
9:35 – 9:55Invited Speaker: TBD
Title: TBD
9:55 – 10:15 Invited Speaker: 田卫东，教授，复旦大学
Title: Explaining the disease phenotype of intergenic SNPs using predicted target genes
10:15 – 10:40 Tea Break
10:40 – 12:00Invited Session 9: Biostatistics
Chair: Haiqun Lin
10:40 – 11:00 Invited Speaker:邓明华，教授，北京大学
Title: Network Inference of microbial communities from metagenome data
11:00 – 11:20 Invited Speaker:Hua Zhong, Assistant Professor, New York University
Title: Estimation of sparse directed acyclic graphs through a lasso framework and its applications
11:20 – 11:40 Invited Speaker: 侯琳，助理教授，清华大学
Title: The impact of genotyping errors on the statistical power of association test in genome-wide association studies
11:40 – 12:00 Invited Speaker: 王涛，特别研究员，上海交通大学
Title: Structured subcomposition selection in regression and its application to microbiome data analysis
12:00 – 13:30 Lunch
13:30 – 14:50Invited Session 10: Big Omics Data Analysis
Chair: Gang Feng
13:30 – 13:50 Invited Speaker:刘雷，教授，复旦大学
Title:
13:50 – 14:10 Invited Speaker:李婧，副教授，上海交通大学
Title: Assessment of mutation and modification in cancer proteomics
14:10 – 14:30 Invited Speaker:王卓，副教授，上海交通大学
Title: Omics-Integrated Metabolic Network and Application in the Study of Cancer Metabolism
14:30 – 14:50 Invited Speaker: 陈海峰，副教授，上海交通大学
Title: Intrinsically Disordered Proteins Force Filed ff99IDPs for Biophysics Big Data Analysis
14:50 – 15:15 Tea Break
15:15 – 16:35Invited Session 11: Bioinformatics
Chair: 刘雷
15:15 – 15:35Invited Speaker:Zhaohui Qin, Associate Professor, Emory University
Title: Improving Hierarchical models using historical data
15:35 – 15:55 Invited Speaker:曹志伟，教授，同济大学
Title: Searching synergistic drug combinations to treat cancer
15:55 – 16:15 Invited Speaker: Weichuan Yu, Associate Professor, Hong Kong University of Science and Technology
Title: Estimating Reproducibility in Genome-Wide Association Studies
16:15 – 16:35 Invited Speaker: Dawei Li, Assistant Professor, The University of Vermont
Title: Genome-wide CNV study of addiction
16:35 – 16:45 Closing remarks
END
Speakers:
Wing Wong, Professor, Stanford University
Paul Cleary, Professor, Yale University
Xihong Lin, Professor, Harvard University
Ying Lu, Professor, Stanford University
X. Shirley Liu, Professor, Harvard University
Hongye Sun, VP of Operation Technology Platform, WuXi Apptec Inc
Naitee Ting, Senior Principal Biostatistician, Boehringer Ingelheim Pharmaceuticals
Hongyu Zhao, Professor, Yale University
Yi Li, Professor, The University of Michigan
Peter X.K. Song, Professor, The University of Michigan
Ming Yuan, Professor, The University of Wisconsin-Madison
Ying Yuan, Associate Professor, MD Anderson Cancer Center
Hua Xu, Professor, The University of Texas Health Science Center
Ying Zhang, Professor, Indiana University
Rui Xiao, Associate Professor, The University of Pennsylvania
Mingyao Li, Associate Professor, The University of Pennsylvania
Zhaohui Qin, Associate Professor, Emory University
Qi Long, Associate Professor, Emory University
Weichuan Yu, Associate Professor, Hong Kong University of Science and Technology
Tiejun Tong, Associate Professor, Hong Kong Baptist University
Hua Zhong, Assistant Professor, New York University
Herbert Pang, Assistant Professor, The University of Hong Kong
Dawei Li, Assistant Professor, The University of Vermont
Dajiang Liu, Assistant Professor, Pennsylvania State University
Can Yang, Assistant Professor, Hong Kong Baptist University
赵国屏，中国科学院院士
李亦学，教授，中国科学院
陈洛南，教授，中国科学院
赵东升，教授，军事医学科学院
韩宝惠，教授，上海胸科医院
李程，教授，北京大学
邓明华，教授，北京大学
刘雷，教授，复旦大学
胡跃清，教授，复旦大学
田卫东，教授，复旦大学
张淑芹，副教授，复旦大学
曹志伟，教授，同济大学
黄伟，副教授，东北师范大学
侯琳，助理教授，清华大学
吕晖，教授，上海交通大学
俞章盛，教授，上海交通大学
韦朝春，教授，上海交通大学
陈海峰，副教授，上海交通大学
王炳顺，教授，上海交通大学
李婧，副教授，上海交通大学
王卓，副教授，上海交通大学
王涛，特别研究员，上海交通大学
会议基本信息：
会议时间：
2016年6月30日-7月2日
会议地点：
中国 .上海
上海交通大学徐汇校区浩然大厦一楼102会议室
组委会主席：赵宏宇 吕晖
组委会委员：张显明 孙洁林 俞章盛 王炳顺 马政
组委会秘书长：王涛
工作组：冯兆莹 曹祎 丛珊
参会方式：
请有意向参会的人员，通过微信填写注册回执，或者以电子邮件的方式发送回执至yicao@sjtu.edu.cn.
